Lawrence David, Teresa McDonald, and colleagues, will use Global Grant for Gut Health to study infants in Nicaragua

Childhood and infancy are critical periods during the human lifespan, yet we know very little about gut microbiome development. Their project will focus on children from a community in Nicaragua who are at risk of diarrheal illness. Sylvia Becker-Dreps, the physician scientist shaping the clinical aspects of our work, together with Nicaraguan virologist Filemon Bucardo and bacteriologist Samuel Vilchez, has spent nearly two decades examining factors that affect infectious disease risk among kids in Nicaragua and other countries. In their proposed project here, they will measure the diversity of foods that the infants eat as they grow, and connect this to the maturation and composition of the gut microbiome and overall infant health.